PBS Biotech, headquartered in Camarillo, California, USA, has established itself as a key participant in the field of cell therapy since its inception in 2006. The company, which specializes in single-use bioreactor systems and provides entire process development services, is well-known for its creative solutions.

PBS Biotech's contributions to the market revolve around the Vertical-Wheel bioreactor, a novel technology designed specifically for cell therapy manufacturing. In contrast to previous approaches, this bioreactor is scalable, allowing the manufacturing process to be tailored to specific production requirements. This versatility is critical in the dynamic landscape of cell therapy, where multiple production scales are frequently required.

One significant feature of the Vertical-Wheel bioreactor is its potential to streamline process development for clients. This suggests that companies who use PBS Biotech's technology can shorten their product development cycles, bringing medicines to market more quickly. In the context of developing medicines, where speed can have a direct impact on patient outcomes, this quick turnaround is critical.

PBS Biotech's Research and Development Facility

PBS Biotech's Research and Development Facility PBS Biotech's Bioprocess Research & Development team is highly regarded for its expertise in cell culture processes, focusing on various therapeutic cell types including iPSCs and MSCs. Working from a state-of-the-art laboratory on site, this team delivers top-tier contract process development services to clients globally.

• Cellular Cultivation Mastery: PBS Biotech's Bioprocess Research & Development team is internationally recognized for its proficiency in cell culture processes, specializing in therapeutic cell types such as iPSCs and MSCs. • Outstanding Contract Process Development: Leveraging their advanced onsite laboratory, the team offers exceptional contract process development services to clients around the world, ensuring top-notch results.
• Cutting-edge Facility: PBS Biotech operates within an innovative 63,800 sq. ft. facility, complete with a dedicated cleanroom and manufacturing areas. Within this space, they assemble single-use vessels and electro-mechanical bioreactors. • Strict Quality Standards: All products undergo rigorous in-house assembly and inspection processes, ensuring they not only meet but surpass the highest quality standards in therapeutic cell manufacturing.
• Significant Funding: In early 2023, PBS Biotech secured substantial funding from prominent investors such as Avego Management, LLC, and BroadOak Capital Partners. This influx of funding empowered the company to expand its product portfolio and bolster its process development capabilities, facilitating global expansion and client support.
• Worldwide Vision: PBS Biotech aims to establish itself as the global benchmark in manufacturing platforms for allogeneic cell-based therapies. Their mission is to facilitate potential cures for serious conditions like diabetes, cancer, and heart disease, showcasing a strong dedication to innovation and excellence.
• Pioneering Cell Therapy: With an enduring commitment to innovation and excellence, PBS Biotech continues to spearhead advancements in the field of cell therapy, offering hope and potential solutions to patients across the globe.

Vertical-Wheel^®: Redefining Suspension Cultures

Presenting an innovative solution to suspension cultures, the Vertical-Wheel^® impeller emerges as a pioneering advancement, offering an optimal fluid mixing environment tailored for sensitive therapeutic cells. Within its unique U-shaped vessel, the Vertical-Wheel impeller accomplishes complete suspension and mild agitation of anchorage-dependent human cells, which are highly susceptible to the hydrodynamic conditions within a bioreactor. A key benefit is its capacity to faithfully reproduce cell culture processes and hydrodynamic conditions refined at a small scale when transitioning to larger volumes.

Product Development: Achieve Optimal Process Performance

Embark on a journey of excellence in cell culture process development with the dedicated assistance of PBS Biotech's BioLab team. Committed to tailoring scalable solutions precisely to your product and specifications, our team stands ready to elevate the quality and efficiency of your processes.

At the heart of our endeavor is a team of acclaimed scientists and chemical engineers renowned for their industry-leading skills in developing cell culture procedures. With a deep understanding of the complexities involved in therapeutic cell cultivation, our experts specialize in crafting scalable processes that are not only efficient but also seamlessly transferable across different technology platforms.

Clients partnering with PBS Biotech have experienced significant breakthroughs, marking milestones that propel their projects forward. One notable achievement includes the successful scaling up of Pluripotent Stem Cell (PSC) cultures, a critical step towards advancing into pivotal first-in-human trials.

PBS Biotech represents a beacon of proficiency and innovation in the field. Our team's expertise and dedication ensure that clients receive tailored solutions that meet the highest standards of quality and efficacy. Whether you're navigating the challenges of scaling up production or preparing for crucial clinical trials, PBS Biotech is your trusted partner for success in cell therapy development.

Brian Lee, Ph.D. | Founder and CEO

Dr. Lee brings over 25 years of research, management, and leadership experience in biopharmaceutical R&D, bioprocess scale-up, and biomanufacturing with Amgen and Merck.

“Through our revolutionary technologies, such as the Vertical-Wheel^® impeller and our state-of-the-art Research and Development Facility, coupled with our team's unparalleled expertise, we are not just shaping the future of therapeutic cell manufacturing but also advancing the frontiers of medicine.”